Name

CHEK1 Gene

checkpoint kinase 1

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

chek1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term chek1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CHEK1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CHEK1 from the curated KEA Substrates of Kinases dataset.

CHEK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CHEK1 from the Pathway Commons Protein-Protein Interactions dataset.

CHEK1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CHEK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Ubiquitin E3 ligase (CHEK1, CUL4A) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CHEK1, CUL4A) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CHEK1, CUL1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CHEK1, CUL1) protein complex from the CORUM Protein Complexes dataset.

CHEK1_knockdown_142_GSE31912 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CHEK1_knockdown_142_GSE31912 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CHEK1_knockdown_136_GSE31534 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CHEK1_knockdown_136_GSE31534 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CHEK1_knockdown_95_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CHEK1_knockdown_95_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

SC-7898 (CHEK1) Gene Set

From NURSA Protein Complexes

proteins in the SC-7898 (CHEK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL235 (CHEK1) Gene Set

From NURSA Protein Complexes

proteins in the BL235 (CHEK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SC-8408 (CHEK1) Gene Set

From NURSA Protein Complexes

proteins in the SC-8408 (CHEK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.