Name

CHMP2B Gene

charged multivesicular body protein 2B

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]

chmp2b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term chmp2b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CHMP2B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CHMP2B from the Pathway Commons Protein-Protein Interactions dataset.

chmp2bintron5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term chmp2bintron5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.