Name

CKAP5 Gene

cytoskeleton associated protein 5

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

ckap5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ckap5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CKAP5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CKAP5 from the Pathway Commons Protein-Protein Interactions dataset.