Name

CLDN8 Gene

claudin 8

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

cldn8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cldn8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CLDN8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CLDN8 from the Pathway Commons Protein-Protein Interactions dataset.