Name

COL18A1 Gene

collagen, type XVIII, alpha 1

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

COL18A1-AS2 Gene

COL18A1 antisense RNA 2

COL18A1-AS1 Gene

COL18A1 antisense RNA 1

col18a1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term col18a1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

COL18A1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COL18A1 from the Pathway Commons Protein-Protein Interactions dataset.