Name

COX1 Gene

COX19 Gene

COX19 cytochrome c oxidase assembly factor

COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]

COX17P1 Gene

COX17 cytochrome c oxidase copper chaperone pseudogene 1

COX14 Gene

COX14 cytochrome c oxidase assembly factor

This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

COX18 Gene

COX18 cytochrome c oxidase assembly factor

This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

COX10 Gene

COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]

COX11 Gene

COX11 cytochrome c oxidase copper chaperone

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

COX15 Gene

cytochrome c oxidase assembly homolog 15 (yeast)

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]

COX16 Gene

COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)

COX17 Gene

COX17 cytochrome c oxidase copper chaperone

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

COX11P1 Gene

COX11 cytochrome c oxidase copper chaperone pseudogene 1

SYNJ2BP-COX16 Gene

SYNJ2BP-COX16 readthrough

This locus represents naturally occurring read-through transcription between the neighboring SYNJ2BP (synaptojanin 2 binding protein) and COX16 (COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)) genes on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2011]

COX10-AS1 Gene

COX10 antisense RNA 1

cox1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

COX1 homodimer complex Gene Set

From CORUM Protein Complexes

proteins in the COX1 homodimer complex protein complex from the CORUM Protein Complexes dataset.

cox1pgi2ppardelta Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox1pgi2ppardelta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox1b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox1b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox1b1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox1b1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox17mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox17mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox19 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox19 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox15 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox15 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cox17 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cox17 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Cytochrome c oxidase assembly protein CtaG/Cox11, domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cytochrome c oxidase assembly protein CtaG/Cox11, domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

COX15/CtaA family Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the COX15/CtaA family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cytochrome c oxidase assembly protein CtaG/Cox11 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cytochrome c oxidase assembly protein CtaG/Cox11 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cytochrome c oxidase assembly protein COX14 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cytochrome c oxidase assembly protein COX14 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cytochrome c oxidase assembly protein COX16 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cytochrome c oxidase assembly protein COX16 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

COX18 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX18 from the Pathway Commons Protein-Protein Interactions dataset.

COX19 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX19 from the Pathway Commons Protein-Protein Interactions dataset.

COX11 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX11 from the Pathway Commons Protein-Protein Interactions dataset.

COX14 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX14 from the Pathway Commons Protein-Protein Interactions dataset.

COX15 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX15 from the Pathway Commons Protein-Protein Interactions dataset.

COX16 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX16 from the Pathway Commons Protein-Protein Interactions dataset.

COX17 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for COX17 from the Pathway Commons Protein-Protein Interactions dataset.