Name

CPSF4 Gene

cleavage and polyadenylation specific factor 4, 30kDa

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

CPSF4L Gene

cleavage and polyadenylation specific factor 4-like

cpsf4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cpsf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CPSF4 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CPSF4 from the NURSA Protein-Protein Interactions dataset.

CPSF4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CPSF4 from the Pathway Commons Protein-Protein Interactions dataset.