Name

CRLF2 Gene

cytokine receptor-like factor 2

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

crlf2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term crlf2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CRLF2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CRLF2 from the Pathway Commons Protein-Protein Interactions dataset.

crlf2high Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term crlf2high in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

crlf2jak2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term crlf2jak2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

crlf2positive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term crlf2positive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.