Name

CSH1 Gene

chorionic somatomammotropin hormone 1 (placental lactogen)

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

csh1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term csh1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CSH1 Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the CSH1 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

CSH1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CSH1 from the Pathway Commons Protein-Protein Interactions dataset.

csh101 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term csh101 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.