Name

CTLA4 Gene

cytotoxic T-lymphocyte-associated protein 4

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

ctla4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CTLA4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTLA4 from the Pathway Commons Protein-Protein Interactions dataset.

ctla4 cd28 haplotypes Gene Set

From GAD Gene-Disease Associations

genes associated with the disease ctla4 cd28 haplotypes in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

ctla4318ct Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4318ct in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4ig Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4ig in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4atn Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4atn in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4cd28 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4cd28 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4b7 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4b7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla449 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla449 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4icos Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4icos in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4trimlaxrab8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4trimlaxrab8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4aptstat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4aptstat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla41722tc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla41722tc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4fasl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4fasl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctla4il13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctla4il13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CTLA4 inhibitory signaling Gene Set

From Reactome Pathways

proteins participating in the CTLA4 inhibitory signaling pathway from the Reactome Pathways dataset.