cathepsin B

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ctsb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CTSB Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CTSB from the MSigDB Cancer Gene Co-expression Modules dataset.

CTSB Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSB from the Pathway Commons Protein-Protein Interactions dataset.