cathepsin K

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

ctsk Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CTSK Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSK from the Pathway Commons Protein-Protein Interactions dataset.