Name

CYP19A1 Gene

cytochrome P450, family 19, subfamily A, polypeptide 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

cyp19a1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp19a1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CYP19A1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CYP19A1 from the Pathway Commons Protein-Protein Interactions dataset.

Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Gene Set

From Reactome Pathways

proteins participating in the Defective CYP19A1 causes Aromatase excess syndrome (AEXS) pathway from the Reactome Pathways dataset.