Name

CYP3A5 Gene

cytochrome P450, family 3, subfamily A, polypeptide 5

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CYP3A51P Gene

cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene

This locus represents a CYP3A pseudogene that is present within a cluster of CYP3A (cytochrome P450, family 3, subfamily A) genes on chromosome 7. This pseudogene is located between the CYP3A7 and CYP3A5 family members. It contains duplicates of exons 1, 2 and 13 that are found in the functional genes. Readthrough transcription exists between the CYP3A7 gene and this pseudogene, where the readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of this pseudogene, as represented in GeneID:100861540. This pseudogene is not known to be independently transcribed. [provided by RefSeq, Feb 2012]

CYP3A7-CYP3A51P Gene

CYP3A7-CYP3A51P readthrough

This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the CYP3A gene cluster on chromosome 7. The downstream pseudogene is not known to be independently transcribed. The readthrough transcript includes CYP3A7 exons 1-13 and exons 2 and 13 of the pseudogene. It encodes a CYP3A isoform with a novel C-terminus. This isoform is only expressed in alleles containing a T nucleotide at the -6 position of a splice acceptor in the pseudogene, which enables correct splicing of the upstream CYP3A7 exons to the pseudogene exons. It should be noted that the reference genome sequence represents the CYP3A7_39256 T->A allele, and thus this haplotype is unlikely to produce the readthrough transcript. [provided by RefSeq, Jan 2015]

cyp3a5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CYP3A5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CYP3A5 from the Pathway Commons Protein-Protein Interactions dataset.

cyp3a5 levels Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp3a5 levels in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp3a5 expression Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp3a5 expression in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp3a51 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a51 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cyp3a55 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a55 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cyp3a513 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a513 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cyp3a511 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a511 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cyp3a53 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a53 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cyp3a531 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a531 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cyp3a533 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp3a533 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.