Name

CYSLTR1 Gene

cysteinyl leukotriene receptor 1

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

cysltr1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cysltr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CYSLTR1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CYSLTR1 from the Pathway Commons Protein-Protein Interactions dataset.