Name

DEFA6 Gene

defensin, alpha 6, Paneth cell-specific

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]

defa6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term defa6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DEFA6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DEFA6 from the Pathway Commons Protein-Protein Interactions dataset.