Name

DFFA Gene

DNA fragmentation factor, 45kDa, alpha polypeptide

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DFFA Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for DFFA from the MSigDB Cancer Gene Co-expression Modules dataset.

DFFA Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for DFFA from the NURSA Protein-Protein Interactions dataset.

DFFA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DFFA from the Pathway Commons Protein-Protein Interactions dataset.

BL5726 (DFFA) Gene Set

From NURSA Protein Complexes

proteins in the BL5726 (DFFA) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.