Name

DHFR Gene

dihydrofolate reductase

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

DHFRL1 Gene

dihydrofolate reductase-like 1

DHFRP2 Gene

dihydrofolate reductase pseudogene 2

DHFRP1 Gene

dihydrofolate reductase pseudogene 1

dhfr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dhfr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DHFR Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DHFR from the Pathway Commons Protein-Protein Interactions dataset.

DHFRL1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DHFRL1 from the Pathway Commons Protein-Protein Interactions dataset.