DIO2 Gene

deiodinase, iodothyronine, type II

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

DIO2-AS1 Gene

DIO2 antisense RNA 1

dio2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dio2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DIO2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DIO2 from the Pathway Commons Protein-Protein Interactions dataset.