Name

DMD Gene

dystrophin

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008]

DMD-AS3 Gene

DMD antisense RNA 3

dmd Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dmd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DMD Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DMD from the Pathway Commons Protein-Protein Interactions dataset.

Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1472 Gene Set

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1472 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE1026 Gene Set

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE1026 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1008 Gene Set

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1008 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025 Gene Set

From GEO Signatures of Differentially Expressed Genes for Diseases

genes differentially expressed during Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals) Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

DMD_Deficiency_GDS2996_614_mouse_Cardiac muscles from 10.5-month (mdx animals) Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the DMD_Deficiency_GDS2996_614_mouse_Cardiac muscles from 10.5-month (mdx animals) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA protein domain from the InterPro Predicted Protein Domain Annotations dataset.