DUSP4 Gene

dual specificity phosphatase 4

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

DUSP4 Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase DUSP4 from the curated DEPOD Substrates of Phosphatases dataset.

dusp4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dusp4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DUSP4 Gene Set

From KEA Substrates of Kinases

substrates of the kinase DUSP4 from the curated KEA Substrates of Kinases dataset.

DUSP4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DUSP4 from the Pathway Commons Protein-Protein Interactions dataset.