Name

DUSP6 Gene

dual specificity phosphatase 6

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

DUSP6 Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase DUSP6 from the curated DEPOD Substrates of Phosphatases dataset.

dusp6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dusp6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DUSP6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DUSP6 from the Pathway Commons Protein-Protein Interactions dataset.

dusp6mkp3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dusp6mkp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.