DUSP9 Gene

dual specificity phosphatase 9

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]

DUSP9 Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase DUSP9 from the curated DEPOD Substrates of Phosphatases dataset.

DUSP9 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DUSP9 from the Pathway Commons Protein-Protein Interactions dataset.

dusp9mkp4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dusp9mkp4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.