Name

DYRK1A Gene

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

DYRK1AIP2 Gene

DYRK1A interacting protein 2

DYRK1AIP1 Gene

DYRK1A interacting protein 1

dyrk1a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dyrk1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DYRK1A Gene Set

From KEA Substrates of Kinases

substrates of the kinase DYRK1A from the curated KEA Substrates of Kinases dataset.

DYRK1A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for DYRK1A from the Pathway Commons Protein-Protein Interactions dataset.

DYRK1A Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase DYRK1A from the curated PhosphoSitePlus Substrates of Kinases dataset.

dyrk1ainduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dyrk1ainduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

dyrk1amediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term dyrk1amediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.