Name

E2F1 Gene

E2F transcription factor 1

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

E2F1 Gene Set

From CHEA Transcription Factor Targets

target genes of the E2F1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

E2F1 Gene Set

From ENCODE Transcription Factor Targets

target genes of the E2F1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

e2f1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

E2F1 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the E2F1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

E2F1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for E2F1 from the NURSA Protein-Protein Interactions dataset.

E2F1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for E2F1 from the Pathway Commons Protein-Protein Interactions dataset.

E2F1 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the E2F1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

E2F1 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the E2F1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

e2f1 destruction pathway Gene Set

From Biocarta Pathways

proteins participating in the e2f1 destruction pathway pathway from the Biocarta Pathways dataset.

E2F1-17053090-MCF7-human Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the E2F1-17053090-MCF7-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

E2F1-18555785-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the E2F1-18555785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

E2F1-21310950-MCF7-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the E2F1-21310950-MCF7-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

Trip(Br2)-Dp1-E2F1 complex Gene Set

From CORUM Protein Complexes

proteins in the Trip(Br2)-Dp1-E2F1 complex protein complex from the CORUM Protein Complexes dataset.

Trip(Br1)-Dp1-E2F1 complex Gene Set

From CORUM Protein Complexes

proteins in the Trip(Br1)-Dp1-E2F1 complex protein complex from the CORUM Protein Complexes dataset.

CEBPE-E2F1-RB1 complex Gene Set

From CORUM Protein Complexes

proteins in the CEBPE-E2F1-RB1 complex protein complex from the CORUM Protein Complexes dataset.

DNMT1-RB1-HDAC1-E2F1 complex Gene Set

From CORUM Protein Complexes

proteins in the DNMT1-RB1-HDAC1-E2F1 complex protein complex from the CORUM Protein Complexes dataset.

E2F1-Rb complex Gene Set

From CORUM Protein Complexes

proteins in the E2F1-Rb complex protein complex from the CORUM Protein Complexes dataset.

SP1-E2F1 complex Gene Set

From CORUM Protein Complexes

proteins in the SP1-E2F1 complex protein complex from the CORUM Protein Complexes dataset.

E2F1-p107-cyclinA complex Gene Set

From CORUM Protein Complexes

proteins in the E2F1-p107-cyclinA complex protein complex from the CORUM Protein Complexes dataset.

GABP(gamma)1-E2F1-DP1 complex Gene Set

From CORUM Protein Complexes

proteins in the GABP(gamma)1-E2F1-DP1 complex protein complex from the CORUM Protein Complexes dataset.

HA-E2F1_HeLa-S3_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the HA-E2F1_HeLa-S3_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

E2F1_HeLa-S3_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the E2F1_HeLa-S3_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

HA-E2F1_MCF-7_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the HA-E2F1_MCF-7_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

e2f1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1driven Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1driven in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1expressing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1expressing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1target Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1target in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1regulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1regulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1rb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1rb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1qkiprbe2f1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1qkiprbe2f1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1dnmt1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1dnmt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1responsive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1responsive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f14 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f14 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1cdk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1cdk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1yy1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1yy1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1p73dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1p73dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1rhamm Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1rhamm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1mir7egfr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1mir7egfr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1activated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1activated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1binding Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1binding in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

e2f1sp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term e2f1sp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

E2F1_KD_GDS4094_446_mouse_Mammary tumors Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the E2F1_KD_GDS4094_446_mouse_Mammary tumors gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

E2F1_UP.V1 Gene Set

From MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations

genes differentially expressed following the E2F1_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

BL3388 (E2F1) Gene Set

From NURSA Protein Complexes

proteins in the BL3388 (E2F1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL3390 (E2F1) Gene Set

From NURSA Protein Complexes

proteins in the BL3390 (E2F1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SC-251 (E2F1) Gene Set

From NURSA Protein Complexes

proteins in the SC-251 (E2F1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

Inhibition of replication initiation of damaged DNA by RB1/E2F1 Gene Set

From Reactome Pathways

proteins participating in the Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway from the Reactome Pathways dataset.