EEF1E1-BLOC1S5 readthrough (NMD candidate)

This locus represents naturally occurring read-through transcription between the neighboring EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) and MUTED (muted homolog) genes on chromosome 6. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to produce a protein product. [provided by RefSeq, Dec 2010]

EEF1E1 Gene

eukaryotic translation elongation factor 1 epsilon 1

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

eef1e1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term eef1e1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

EEF1E1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for EEF1E1 from the Pathway Commons Protein-Protein Interactions dataset.