Name

ENPP2 Gene

ectonucleotide pyrophosphatase/phosphodiesterase 2

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

enpp2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term enpp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ENPP2 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for ENPP2 from the NURSA Protein-Protein Interactions dataset.

ENPP2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ENPP2 from the Pathway Commons Protein-Protein Interactions dataset.

enpp2autotaxin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term enpp2autotaxin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.