EXOC2 Gene

exocyst complex component 2

The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

exoc2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term exoc2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

EXOC2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for EXOC2 from the Pathway Commons Protein-Protein Interactions dataset.