Name

FH Gene

fumarate hydratase

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]

FHOD1 Gene

formin homology 2 domain containing 1

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq, Jul 2008]

FHOD3 Gene

formin homology 2 domain containing 3

Proteins that contain formin (FMN1; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton (Kanaya et al., 2005 [PubMed 15966898]).[supplied by OMIM, Apr 2010]

FHDC1 Gene

FH2 domain containing 1

FHL2 Gene

four and a half LIM domains 2

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

FHL3 Gene

four and a half LIM domains 3

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

FHL1 Gene

four and a half LIM domains 1

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

FHAD1 Gene

forkhead-associated (FHA) phosphopeptide binding domain 1

FHIT Gene

fragile histidine triad

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

FHII Gene

Hyperaldosteronism, familial, type II

FHASD Gene

Foveal hypoplasia and anterior segment dysgenesis

FHL5 Gene

four and a half LIM domains 5

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2009]

FHP1 Gene

fumarate hydratase pseudogene 1

FH Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FH from the Pathway Commons Protein-Protein Interactions dataset.

MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding protein domain from the InterPro Predicted Protein Domain Annotations dataset.

fhf complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the fhf complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

fhf complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the fhf complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

FHL2-CREB complex Gene Set

From CORUM Protein Complexes

proteins in the FHL2-CREB complex protein complex from the CORUM Protein Complexes dataset.

FHL4/STX11-ACT complex Gene Set

From CORUM Protein Complexes

proteins in the FHL4/STX11-ACT complex protein complex from the CORUM Protein Complexes dataset.

FHL3-CREB complex Gene Set

From CORUM Protein Complexes

proteins in the FHL3-CREB complex protein complex from the CORUM Protein Complexes dataset.

FOXO1-FHL2-SIRT1 complex Gene Set

From CORUM Protein Complexes

proteins in the FOXO1-FHL2-SIRT1 complex protein complex from the CORUM Protein Complexes dataset.

FHL2-ACT complex Gene Set

From CORUM Protein Complexes

proteins in the FHL2-ACT complex protein complex from the CORUM Protein Complexes dataset.

FHL2-FHL3 complex Gene Set

From CORUM Protein Complexes

proteins in the FHL2-FHL3 complex protein complex from the CORUM Protein Complexes dataset.

FHL2 homodimer complex Gene Set

From CORUM Protein Complexes

proteins in the FHL2 homodimer complex protein complex from the CORUM Protein Complexes dataset.

FHL3 homodimer complex Gene Set

From CORUM Protein Complexes

proteins in the FHL3 homodimer complex protein complex from the CORUM Protein Complexes dataset.

FHL2-p53-HIPK2 complex Gene Set

From CORUM Protein Complexes

proteins in the FHL2-p53-HIPK2 complex protein complex from the CORUM Protein Complexes dataset.

transcriptional inactivation of the fhit gene Gene Set

From GAD Gene-Disease Associations

genes associated with the disease transcriptional inactivation of the fhit gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fhitmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhitmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fh1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fh1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fh2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fh2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhm Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhf Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhs Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhitnegative Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhitnegative in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhm2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhm2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhv62i Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhv62i in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhit Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhit in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl1c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl1c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhbl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhbl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhl2betacatenin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhl2betacatenin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhr1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhile62 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhile62 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhod1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhod1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhod3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhod3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhob Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhob in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhitfra3b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhitfra3b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fh14 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fh14 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhde Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhde in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhab Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhab in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

FHL2_Deficiency_GDS3344_596_mouse_Spontaneously immortalized embryonic fibroblasts (EFs) Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the FHL2_Deficiency_GDS3344_596_mouse_Spontaneously immortalized embryonic fibroblasts (EFs) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

fhf complex Gene Set

From GO Cellular Component Annotations

proteins localized to the fhf complex cellular component from the curated GO Cellular Component Annotations dataset.

fha domain binding Gene Set

From GO Molecular Function Annotations

genes performing the fha domain binding molecular function from the curated GO Molecular Function Annotations dataset.

FH2 domain-containing protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FH2 domain-containing protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

FH1/FH2 domain-containing protein 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FH1/FH2 domain-containing protein 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Formin, GTPase-binding and FH3 domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Formin, GTPase-binding and FH3 domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Forkhead-associated (FHA) domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Forkhead-associated (FHA) domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Formin, FH3 domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Formin, FH3 domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Formin, FH2 domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Formin, FH2 domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

SMAD/FHA domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SMAD/FHA domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL1866 (FHL2) Gene Set

From NURSA Protein Complexes

proteins in the BL1866 (FHL2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL1865 (FHL2) Gene Set

From NURSA Protein Complexes

proteins in the BL1865 (FHL2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

FHOD1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHOD1 from the Pathway Commons Protein-Protein Interactions dataset.

FHOD3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHOD3 from the Pathway Commons Protein-Protein Interactions dataset.

FHIT Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHIT from the Pathway Commons Protein-Protein Interactions dataset.

FHL2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHL2 from the Pathway Commons Protein-Protein Interactions dataset.

FHL3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHL3 from the Pathway Commons Protein-Protein Interactions dataset.

FHL1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHL1 from the Pathway Commons Protein-Protein Interactions dataset.

FHL5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHL5 from the Pathway Commons Protein-Protein Interactions dataset.

fhc cell Gene Set

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue fhc cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.