Name

FHIT Gene

fragile histidine triad

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

fhit Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhit in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

FHIT Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FHIT from the Pathway Commons Protein-Protein Interactions dataset.

transcriptional inactivation of the fhit gene Gene Set

From GAD Gene-Disease Associations

genes associated with the disease transcriptional inactivation of the fhit gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fhitmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhitmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhitnegative Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhitnegative in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fhitfra3b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fhitfra3b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.