FKBP4 Gene

FK506 binding protein 4, 59kDa

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

FKBP4P6 Gene

FK506 binding protein 4, 59kDa pseudogene 6

FKBP4P8 Gene

FK506 binding protein 4, 59kDa pseudogene 8

FKBP4P2 Gene

FK506 binding protein 4, 59kDa pseudogene 2

FKBP4P1 Gene

FK506 binding protein 4, 59kDa pseudogene 1

FKBP4P7 Gene

FK506 binding protein 4, 59kDa pseudogene 7

fkbp4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fkbp4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

FKBP4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FKBP4 from the Pathway Commons Protein-Protein Interactions dataset.

BL5747 (FKBP4) Gene Set

From NURSA Protein Complexes

proteins in the BL5747 (FKBP4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.