Name

GAB2 Gene

GRB2-associated binding protein 2

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

gab2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gab2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GAB2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GAB2 from the Pathway Commons Protein-Protein Interactions dataset.

cRET-Shc-Grb2-Gab2-P85PI3K-Shp2 complex Gene Set

From CORUM Protein Complexes

proteins in the cRET-Shc-Grb2-Gab2-P85PI3K-Shp2 complex protein complex from the CORUM Protein Complexes dataset.

gab2dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gab2dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.