Name

GCLC Gene

glutamate-cysteine ligase, catalytic subunit

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

gclc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gclc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GCLC Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GCLC from the Pathway Commons Protein-Protein Interactions dataset.

gclcat Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gclcat in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Gene Set

From Reactome Pathways

proteins participating in the Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) pathway from the Reactome Pathways dataset.