Name

GFI1 Gene

growth factor independent 1 transcription repressor

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

GFI1B Gene

growth factor independent 1B transcription repressor

This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

gfi1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gfi1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GFI1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GFI1 from the Pathway Commons Protein-Protein Interactions dataset.

GFI1 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the GFI1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

GFI1 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the GFI1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

GFI1B-20887958-HPC-7-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the GFI1B-20887958-HPC-7-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

GFI1B Gene Set

From CHEA Transcription Factor Targets

target genes of the GFI1B transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Gata1-Gfi1b complex Gene Set

From CORUM Protein Complexes

proteins in the Gata1-Gfi1b complex protein complex from the CORUM Protein Complexes dataset.

gfi1b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gfi1b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gfi1gata2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gfi1gata2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gfi1bgata1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gfi1bgata1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GFI1_KO_GDS4204_147_mouse_HSC Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the GFI1_KO_GDS4204_147_mouse_HSC gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

Gfi1b_OE_GDS4302_425_mouse_AMuLV (pro-B Abelson leukemia virus transformed) cell line Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the Gfi1b_OE_GDS4302_425_mouse_AMuLV (pro-B Abelson leukemia virus transformed) cell line gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

Gfi1b Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the Gfi1b transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

GFI1B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GFI1B from the Pathway Commons Protein-Protein Interactions dataset.