Name

GHR Gene

growth hormone receptor

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

GHRH Gene

growth hormone releasing hormone

The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

GHRLOS Gene

ghrelin opposite strand/antisense RNA

This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs. [provided by RefSeq, Jan 2013]

GHRL Gene

ghrelin/obestatin prepropeptide

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]

GHRHR Gene

growth hormone releasing hormone receptor

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

ghr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GHR Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GHR from the Pathway Commons Protein-Protein Interactions dataset.

elevated response to ghrh by pituitary somatotrophinomas Gene Set

From GAD Gene-Disease Associations

genes associated with the disease elevated response to ghrh by pituitary somatotrophinomas in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

ghrelin receptor Gene Set

From GAD Gene-Disease Associations

genes associated with the disease ghrelin receptor in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

ghrelins Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelins in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghreceptor Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghreceptor in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinleptin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinleptin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrd3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrd3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrlos Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrlos in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrh Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrh in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghreview Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghreview in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrhigf1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrhigf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrexon3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrexon3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinnpy Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinnpy in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelininduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelininduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinoacyltransferase Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinoacyltransferase in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrprlr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrprlr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrs Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinghsr1a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinghsr1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghreleasing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghreleasing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinigfi Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinigfi in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrhr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrhr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrhinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrhinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelingrowth Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelingrowth in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinassociated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinassociated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelinghsr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ghrelinghsr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ghrelin receptor binding Gene Set

From GO Molecular Function Annotations

genes performing the ghrelin receptor binding molecular function from the curated GO Molecular Function Annotations dataset.

GHRH-(1-29)-OH (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the GHRH-(1-29)-OH (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

[125I]GHRH (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [125I]GHRH (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

GHRP-6 Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the GHRP-6 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

GHRP-2 Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the GHRP-2 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

GHRH-(1-29)-NH2 (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the GHRH-(1-29)-NH2 (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

[125I][His9]ghrelin (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [125I][His9]ghrelin (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

[Ac-Tyr1 D-Arg2]GHRH-(1-29)-NH2 (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Ac-Tyr1 D-Arg2]GHRH-(1-29)-NH2 (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

[125I][Tyr4]ghrelin (human) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [125I][Tyr4]ghrelin (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

GHRH-(1-29)-NH2 (rat) Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the GHRH-(1-29)-NH2 (rat) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

GHRH Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the GHRH ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

GHRL Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the GHRL ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

Motilin/ghrelin-associated peptide Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Motilin/ghrelin-associated peptide protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Motilin/ghrelin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Motilin/ghrelin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

decreased circulating ghrelin level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased circulating ghrelin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

increased circulating ghrelin level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the increased circulating ghrelin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

abnormal circulating ghrelin level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal circulating ghrelin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

?isolated growth hormone deficiency due to defect in ghrf Gene Set

From OMIM Gene-Disease Associations

genes associated with the ?isolated growth hormone deficiency due to defect in ghrf phenotype from the curated OMIM Gene-Disease Associations dataset.

gigantism due to ghrf hypersecretion Gene Set

From OMIM Gene-Disease Associations

genes associated with the gigantism due to ghrf hypersecretion phenotype from the curated OMIM Gene-Disease Associations dataset.

GHRL Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GHRL from the Pathway Commons Protein-Protein Interactions dataset.

GHRH Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GHRH from the Pathway Commons Protein-Protein Interactions dataset.

GHRHR Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GHRHR from the Pathway Commons Protein-Protein Interactions dataset.

Synthesis, secretion, and deacylation of Ghrelin Gene Set

From Reactome Pathways

proteins participating in the Synthesis, secretion, and deacylation of Ghrelin pathway from the Reactome Pathways dataset.