Name

GLI3 Gene

GLI family zinc finger 3

This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

gli3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gli3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GLI3 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the GLI3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

GLI3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GLI3 from the Pathway Commons Protein-Protein Interactions dataset.

gli3zic3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gli3zic3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gli3target Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gli3target in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

GLI3 is processed to GLI3R by the proteasome Gene Set

From Reactome Pathways

proteins participating in the GLI3 is processed to GLI3R by the proteasome pathway from the Reactome Pathways dataset.