Name

GRIA2 Gene

glutamate receptor, ionotropic, AMPA 2

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

gria2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gria2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GRIA2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GRIA2 from the Pathway Commons Protein-Protein Interactions dataset.