Name

GRIA4 Gene

glutamate receptor, ionotropic, AMPA 4

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

gria4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gria4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GRIA4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GRIA4 from the Pathway Commons Protein-Protein Interactions dataset.