glutamate receptor, ionotropic, N-methyl D-aspartate 2A

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

grin2a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term grin2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GRIN2A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GRIN2A from the Pathway Commons Protein-Protein Interactions dataset.

Grin2a-Lrp8 complex Gene Set

From CORUM Protein Complexes

proteins in the Grin2a-Lrp8 complex protein complex from the CORUM Protein Complexes dataset.