Name

GRM1 Gene

glutamate receptor, metabotropic 1

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

grm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term grm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GRM1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GRM1 from the Pathway Commons Protein-Protein Interactions dataset.