Name

GRPR Gene

gastrin-releasing peptide receptor

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

grpr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term grpr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GRPR Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GRPR from the Pathway Commons Protein-Protein Interactions dataset.

grpreceptor Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term grpreceptor in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

grprmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term grprmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.