GSTA4 Gene

glutathione S-transferase alpha 4

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]

GSTA4 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for GSTA4 from the MSigDB Cancer Gene Co-expression Modules dataset.

GSTA4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GSTA4 from the Pathway Commons Protein-Protein Interactions dataset.

gsta44 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gsta44 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.