Name

GSTM1 Gene

glutathione S-transferase mu 1

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

gstm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GSTM1 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for GSTM1 from the MSigDB Cancer Gene Co-expression Modules dataset.

GSTM1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GSTM1 from the Pathway Commons Protein-Protein Interactions dataset.

gstm1gstt1double Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1gstt1double in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1nonnull Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1nonnull in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1ve Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1ve in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1gstt1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1gstt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm10gsta1a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm10gsta1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1gstt1gstp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1gstt1gstp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1null Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1null in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1gstm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1gstm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1gst Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1gst in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1t1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1t1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm122 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm122 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gstm1glutathione Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gstm1glutathione in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.