3-hydroxyanthranilate 3,4-dioxygenase

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]

haao Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term haao in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

HAAO Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HAAO from the Pathway Commons Protein-Protein Interactions dataset.