Harmonizome

histone deacetylase 3

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hdac3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein HDAC3 from the curated Hub Proteins Protein-Protein Interactions dataset.

From NURSA Protein-Protein Interactions

interacting proteins for HDAC3 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HDAC3 from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the ANCO1-HDAC3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NCOR-HDAC3 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hdac3dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hdac3mbd1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the HDAC3_KO_GDS4886_66_mouse_Heart gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the HDAC3_KO_GDS4886_29_mouse_heart - 6 week old gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From NURSA Protein Complexes

proteins in the BL2128 (HDAC3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2126 (HDAC3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2125 (HDAC3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2127 (HDAC3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.