Name

HPSE Gene

heparanase

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

HPSE2 Gene

heparanase 2 (inactive)

This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

hpse Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hpse in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

HPSE Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HPSE from the Pathway Commons Protein-Protein Interactions dataset.

hpsenegative Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hpsenegative in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

hpse1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hpse1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

hpse2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hpse2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

hpsepositive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hpsepositive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

HPSE2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HPSE2 from the Pathway Commons Protein-Protein Interactions dataset.