Name

HYAL3 Gene

hyaluronoglucosaminidase 3

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

hyal3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hyal3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

HYAL3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for HYAL3 from the Pathway Commons Protein-Protein Interactions dataset.