Name

IL18 Gene

interleukin 18

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

IL18RAP Gene

interleukin 18 receptor accessory protein

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

IL18BP Gene

interleukin 18 binding protein

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

IL18R1 Gene

interleukin 18 receptor 1

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

il18 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL18 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL18 from the Pathway Commons Protein-Protein Interactions dataset.

il18induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18rbeta Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18rbeta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18183 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18183 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18bp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18bp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18r1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18r1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18il18bp Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18il18bp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18ralpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18ralpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18105ac Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18105ac in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18rap Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18rap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18enhanced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18enhanced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il18137607 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il18137607 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL18RAP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL18RAP from the Pathway Commons Protein-Protein Interactions dataset.

IL18BP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL18BP from the Pathway Commons Protein-Protein Interactions dataset.

IL18R1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL18R1 from the Pathway Commons Protein-Protein Interactions dataset.