Name

IL24 Gene

interleukin 24

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

il24 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il24 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL24 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL24 from the Pathway Commons Protein-Protein Interactions dataset.

il24induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il24induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.