Name

IL31 Gene

interleukin 31

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

IL31RA Gene

interleukin 31 receptor A

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

il31 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il31 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il31ra Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il31ra in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL31RA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL31RA from the Pathway Commons Protein-Protein Interactions dataset.